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Article

A complex bilateral polysyndactyly disease locus maps to chromosome 7q36.

Nature genetics - 1 Mar 1994

Tsukurov O, Boehmer A, Flynn J, Nicolai J P, Hamel B C, Traill S, Zaleske D, Mankin H J, Yeon H, Ho C

Abstract excerpt

We demonstrated that the gene responsible for a congenital limb deformity (polysyndactyly) maps to chromosome 7q36 in a large family. Pre- and postaxial anomalies of the extremities are inherited in this family as an autosomal dominant trait. The disease locus is closely linked to D7S550 (maximum lod score = 6.85, theta = 0). This region is homologous to a segment of mouse chromosome 5, where the mutations hammer...

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PMID: 8012391
DOI: 10.1038/ng0394-282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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