A complex bilateral polysyndactyly disease locus maps to chromosome 7q36.

doi:10.1038/ng0394-282

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Article

A complex bilateral polysyndactyly disease locus maps to chromosome 7q36.

Nature genetics - 1 Mar 1994

Tsukurov O, Boehmer A, Flynn J, Nicolai J P, Hamel B C, Traill S, Zaleske D, Mankin H J, Yeon H, Ho C

Abstract excerpt

We demonstrated that the gene responsible for a congenital limb deformity (polysyndactyly) maps to chromosome 7q36 in a large family. Pre- and postaxial anomalies of the extremities are inherited in this family as an autosomal dominant trait. The disease locus is closely linked to D7S550 (maximum lod score = 6.85, theta = 0). This region is homologous to a segment of mouse chromosome 5, where the mutations hammer...

Topics

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 7
DNA Primers
Female
Genes, Dominant
Genetic Linkage
Genetic Markers
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligodeoxyribonucleotides

Pedigree

Polydactyly

Repetitive Sequences, Nucleic Acid

Syndactyly

Source

Open in PubMed

Identifiers

PMID: 8012391
DOI: 10.1038/ng0394-282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8012391-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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