Phenotypic heterogeneity of an adult form of adrenoleukodystrophy in monozygotic twins.

doi:10.1002/ana.410360617

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Article

Phenotypic heterogeneity of an adult form of adrenoleukodystrophy in monozygotic twins.

Annals of neurology - 1 Dec 1994

Sobue G, Ueno-Natsukari I, Okamoto H, Connell T A, Aizawa I, Mizoguchi K, Honma M, Ishikawa G, Mitsuma T, Natsukari N

Abstract excerpt

We describe genetically proven monozygotic twins with the adult form of adrenoleukodystrophy with significant phenotypic heterogeneity. Myeloneuropathy was common to both patients, but cognitive impairment and affective symptoms with extensive demyelination in the brain were prominent in the olde...

Topics

Adrenoleukodystrophy
Adult
Brain
Diseases in Twins
Genetic Heterogeneity
Humans
Magnetic Resonance Imaging
Male
Pedigree
Phenotype
Twins, Monozygotic

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