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Article

Cells of origin in cancer.

Nature - 20 Jan 2011

Visvader Jane E

Abstract excerpt

Both solid tumours and leukaemias show considerable histological and functional heterogeneity. It is widely accepted that genetic lesions have a major role in determining tumour phenotype, but evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different 'cells of origin'. These cells acquire the first genetic hit or hits that culminate in the initiation of cancer. The...

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PMID: 21248838
DOI: 10.1038/nature09781

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