Article
FMR1 CGG repeat patterns and flanking haplotypes in three Asian populations and their relationship with repeat instability.
Annals of human genetics - 1 Nov 2006
Zhou Youyou, Tang Kun, Law Hai-Yang, Ng Ivy S L, Lee Caroline G L, Chong Samuel S
Abstract excerpt
Hyper-expansion of a CGG repeat in the 5' untranslated region of the FMR1 gene followed by methylation and silencing is the predominant cause of Fragile X syndrome, the most common inherited mental retardation disorder. Most detailed studies of the FMR1 gene have focused on Caucasian populations and patients. We performed a detailed haplotype and linkage disequilibrium analysis of the FMR1 gene in a total of 454...
Topics
- 5' Flanking Region
- Alleles
- Asian People
- Base Sequence
- Chromosomes, Human, X
- Fragile X Mental Retardation Protein
- Genetic Markers
- Genetics, Population
- Haplotypes
- Humans
- Linkage Disequilibrium
- Molecular Sequence Data
- Polymorphism, Single Nucleotide