Article
[Frequency of molecular alterations in heterozygous beta-thalassemia in southern Spain and their relation to the hematologic phenotype].
Sangre - 1 Aug 1994
Molina M A, Romero M J, Abril E, Delgado I, Cano R M, Garrido F, de Pablos J M, Garrido M L
Abstract excerpt
INTRODUCTION: Heterozygous beta-thalassemia manifests hematologically with microcytosis, reduced red blood cell hemoglobin concentration and high hemoglobin A2 levels. Almost all molecular alterations are due to point mutations. We attempt to determinate the frequency of that mutations in the Ori...
Topics
- Base Sequence
- Codon
- DNA Mutational Analysis
- Gene Frequency
- Globins
- Heterozygote
- Humans
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Polymerase Chain Reaction
- Spain
- beta-Thalassemia