Analysis of polymorphic variation in drug metabolism: II. Effects of data transformation on the sensitivity and specificity of modal detection.

Abstract excerpt

Simulations were conducted for a model of drug metabolism involving 2 parallel competing pathways of elimination, wherein the effects of variability in 1 enzyme pathway were examined with respect to variability in recovery of its metabolite and recovery of metabolite through the second, nonvaried, co-eliminating route. Expression of metabolite recoveries as fractions of the total recoverable drug yielded a...

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