Analysis of polymorphic variation in drug metabolism: II. Effects of data transformation on the sensitivity and specificity of modal detection.

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Article

Analysis of polymorphic variation in drug metabolism: II. Effects of data transformation on the sensitivity and specificity of modal detection.

Clinical and investigative medicine. Medecine clinique et experimentale - 1 Aug 1994

Herman R J, Szakas C B, Verbeeck R K

Abstract excerpt

Simulations were conducted for a model of drug metabolism involving 2 parallel competing pathways of elimination, wherein the effects of variability in 1 enzyme pathway were examined with respect to variability in recovery of its metabolite and recovery of metabolite through the second, nonvaried...

Topics

Biotransformation
Computer Simulation
Genetic Variation
Humans
Models, Biological
Pharmaceutical Preparations
Pharmacokinetics
Polymorphism, Genetic
Sensitivity and Specificity
Statistics as Topic

Source

Open in PubMed

Identifiers

PMID: 7982292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7982292-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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