Article
Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat.
Nature genetics - 1 Apr 1993
Cicila G T, Rapp J P, Wang J M, St Lezin E, Ng S C, Kurtz T W
Abstract excerpt
In Dahl salt-hypertension sensitive (S) and resistant (R) strains fed a high NaCl diet, 11 beta-hydroxylase polymorphisms cosegregate with the adrenal capacity to synthesize 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) and blood pressure. The R rat carries an 11 beta-hydroxylase allele that: (i)...
Topics
- Amino Acid Sequence
- Animals
- Blood Pressure
- Cattle
- Chromosome Mapping
- Crosses, Genetic
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypertension
- Male
- Mice
- Molecular Sequence Data
- Point Mutation
- Polymorphism, Restriction Fragment Length
- Rats