The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.

doi:10.1128/JVI.68.12.7918-7926.1994

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Article

The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.

Journal of virology - 1 Dec 1994

Walling D M, Perkins A G, Webster-Cyriaque J, Resnick L, Raab-Traub N

Abstract excerpt

Oral hairy leukoplakia (HLP) lesions frequently contain defective Epstein-Barr virus (EBV) genomes with deletions in the EBNA-2 gene that abundantly replicate and persist within the lesion. To characterize these viral strains and recombinant variants, the EBNA-2 gene in EBV DNA from several different HLP biopsy specimens was analyzed. Amplification of EBNA-2 coding sequences by PCR demonstrated the presence in...

Topics

Amino Acid Sequence
Antigens, Viral
Base Sequence
Codon
DNA-Binding Proteins
Epstein-Barr Virus Nuclear Antigens
Gene Expression
Genes, Viral
Genetic Variation
HIV Seropositivity
Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukoplakia, Oral

Molecular Sequence Data

Oligonucleotide Probes

Point Mutation

Polymerase Chain Reaction

RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 7966582
DOI: 10.1128/JVI.68.12.7918-7926.1994
PMCID: PMC237254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7966582-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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