Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

doi:10.1111/j.1574-6968.1994.tb07140.x

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Article

Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

FEMS microbiology letters - 15 Sept 1994

Kelly S L, Lamb D C, Taylor M, Corran A J, Baldwin B C, Powderly W G

Abstract excerpt

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was obser...

Topics

Acquired Immunodeficiency Syndrome
Amphotericin B
Cryptococcus neoformans
Drug Resistance, Microbial
Humans
Microbial Sensitivity Tests
Mutation
Steroid Isomerases

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