Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence.

doi:10.1038/ng0894-525

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Article

Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence.

Nature genetics - 1 Aug 1994

Rubinsztein D C, Amos W, Leggo J, Goodburn S, Ramesar R S, Old J, Bontrop R, McMahon R, Barton D E, Ferguson-Smith M A

Abstract excerpt

Huntington's disease (HD) correlates with abnormal expansion in a block of CAG repeats in the Huntington's disease gene. We have investigated HD evolution by typing CAG alleles in several human populations and in a variety of primates. We find that human alleles have expanded from a shorter ances...

Topics

Alleles
Animals
Base Sequence
Biological Evolution
Computer Simulation
DNA Primers
Gene Frequency
Haplotypes
Humans
Huntington Disease
Linkage Disequilibrium
Meiosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Minisatellite Repeats

Models, Genetic

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Primates

Source

Open in PubMed

Identifiers

PMID: 7951324
DOI: 10.1038/ng0894-525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7951324-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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