Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence.

Nature genetics - 1 Aug 1994

Rubinsztein D C, Amos W, Leggo J, Goodburn S, Ramesar R S, Old J, Bontrop R, McMahon R, Barton D E, Ferguson-Smith M A

Abstract excerpt

Huntington's disease (HD) correlates with abnormal expansion in a block of CAG repeats in the Huntington's disease gene. We have investigated HD evolution by typing CAG alleles in several human populations and in a variety of primates. We find that human alleles have expanded from a shorter ancestral state and exhibit unusual asymmetric length distributions. Computer simulations are used to show that the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Gene Frequency

Share to Haplotypes

Share to Models, Genetic

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 7951324
DOI: 10.1038/ng0894-525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence.PMID 7951324Read ↗

Epidemiology of Huntington disease.Semantic proximity Read ↗

Huntington disease.Semantic proximity Read ↗

Uncovering the Genetic and Molecular Features of Huntington's Disease in Northern ColombiaSemantic proximity Read ↗

The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population.Semantic proximity Read ↗

Huntington disease: How many repeats does it take?Semantic proximity Read ↗

Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases.Semantic proximity Read ↗

Huntington's disease: nearly four decades of human molecular genetics.Semantic proximity Read ↗

Hunting human disease genes: lessons from the past, challenges for the future.Semantic proximity Read ↗

Uncovering the Genetic and Molecular Features of Huntington's Disease in Northern Colombia.Semantic proximity Read ↗

Propensity for somatic expansion increases over the course of life in Huntington disease.Semantic proximity Read ↗

History of genetic disease: the molecular genetics of Huntington disease - a history.Semantic proximity Read ↗

CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.