Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

doi:10.1080/07391102.1994.10508047

Article

Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

Journal of biomolecular structure & dynamics - 1 Apr 1994

Garnier N, Genest D, Hebert E, Genest M

Abstract excerpt

The c-erbB2 proto-oncogene encodes for a protein of 185kDa (p185) which becomes transforming upon the Val-->Glu transmembrane amino acid substitution. The transforming ability seems to be due to a substitution-resulting constitutive activation of the tyrosine kinase cytosolic domain of the protein. These observations prompted us to evaluate the structural and dynamical behavior of the transmembrane region of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

Abstract excerpt

Topics

Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

Abstract excerpt

Topics

Related research