Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

doi:10.1080/07391102.1994.10508047

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Article

Influence of a mutation in the transmembrane domain of the p185c-erbB2 oncogene-encoded protein studied by molecular dynamics simulations.

Journal of biomolecular structure & dynamics - 1 Apr 1994

Garnier N, Genest D, Hebert E, Genest M

Abstract excerpt

The c-erbB2 proto-oncogene encodes for a protein of 185kDa (p185) which becomes transforming upon the Val-->Glu transmembrane amino acid substitution. The transforming ability seems to be due to a substitution-resulting constitutive activation of the tyrosine kinase cytosolic domain of the protei...

Topics

Amino Acid Sequence
Glutamine
Molecular Sequence Data
Molecular Weight
Mutation
Protein Conformation
Proto-Oncogenes
Receptor, ErbB-2
Valine

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