Catalytic activity of anti-ground state antibodies, antibody subunits, and human autoantibodies.

Abstract excerpt

Catalytic antibodies may be produced over the natural course of antibody-affinity maturation by placement of chemically reactive residues in antibody-active sites by somatic hypermutation or V-D-J-gene rearrangement. This hypothesis has received support from recent observations on the chemical reactivity of antibodies to vasoactive intestinal peptide (VIP), DNA, and steroid- and dinitrophenyl-esters. Recent...

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