Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease.

doi:10.1006/clin.1994.1168

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Article

Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease.

Clinical immunology and immunopathology - 1 Oct 1994

Nijhuis E, Hinloopen B, van Duijn C, Hofman A, Rozing J, Nagelkerken L

Abstract excerpt

Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched contr...

Topics

Aged
Alzheimer Disease
Dexamethasone
Female
Humans
Lymphocyte Activation
Lymphocytes
Male
Phenotype
Sensitivity and Specificity
T-Lymphocytes

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