Article
Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease.
Clinical immunology and immunopathology - 1 Oct 1994
Nijhuis E, Hinloopen B, van Duijn C, Hofman A, Rozing J, Nagelkerken L
Abstract excerpt
Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found between AD patients and age-matched controls with regard to the...
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