Intracellular Antibodies as a New Class of Therapeutic Molecules for Gene Therapy

Abstract excerpt

Intracellularly expressed antibodies, referred to as “intrabodies,” can be designed to bind and inactivate target molecules inside cells. In our previous study, mammalian cells were transduced to produce an anti-gp120 single-chain intrabody sFv105 to inactivate human immunodeficiency virus type-1 (HIV-1) infection. Here, an inducible expression vector was constructed in which the sFv105 intrabody, which reacts...

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