Article
[RFLP-PCR technique for exclusion of carrier status of the mutated Rb gene].
Klinika oczna - 1 Jun 1993
Zajaczek S, Podolski J, Lubiński J, Rosławska A, Krzystolik Z, Sagan Z
Abstract excerpt
Molecular-genetic analysis of DNA by PCR-RFLP technique in a family with a case of unilateral retinoblastoma was performed. The carrier status of mutated Rb gene in a sister of proband was excluded on the basis of molecular analysis despite unsynonymous pedigree data.
Topics
- Child, Preschool
- DNA, Neoplasm
- Family
- Female
- Genes, Retinoblastoma
- Heterozygote
- Humans
- Male
- Mutation
- Pedigree
- Polymorphism, Restriction Fragment Length
- Retinoblastoma