Article
Induction of plasmacytomas in genetically susceptible mice with silicone gels.
Current topics in microbiology and immunology - 1 Jan 1995
Potter M, Morrison S, Miller F
Abstract excerpt
Silicone gels injected intraperitoneally into strains of mice related to BALB/c develop plasmacytomas in approximately the same numbers and with similar phenotypes as previously obtained with pristane. Silicone gels produce few side effects and are well tolerated for long periods. Silicone gels contain several components that are potentially biologically active: residual vinyl groups and platinum. Microscopic and...
Topics
- Animals
- Cell Transformation, Neoplastic
- Chronic Disease
- Gels
- Genetic Predisposition to Disease
- Granuloma
- Injections, Intraperitoneal
- Mice
- Mice, Inbred BALB C
- Oils
- Paraffin
