Innate and adaptive immune responses to the injection of hybrid camouflaging erythrocyte Saccharolobus solfataticus-phosphotriesterase mutant-loaded nanoreactors to mice.

Abstract excerpt

Prophylactic and post-exposure administration of phosphotriesterase-containing polymersome nanoreactors to mice challenged with paraoxon has proven to be very effective against poisoning by this organophosphate compound. The enzyme was an evolved mutant of Saccharolobus solfataricus phosphotriesterase (PTE), a hyperthermophilic archaea enzyme. The enzyme-polymersome nanoreactors (PTE-nRs) were camouflaged into...

Topics

• Animals
• Mice
• Immunity, Innate
• Phosphoric Triester Hydrolases
• Adaptive Immunity
• Erythrocytes
• Cytokines
• Sulfolobus solfataricus
• Mutation
• Polyethylene Glycols