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Article

A side chain at position 48 of the human immunodeficiency virus type-1 protease flap provides an additional specificity determinant.

Virology - 10 Mar 1995

Moody M D, Pettit S C, Shao W, Everitt L, Loeb D D, Hutchison C A, Swanstrom R

Abstract excerpt

Substitution of glycine with glutamic acid at position 48 of the human immunodeficiency virus protease resulted in an enzyme with reduced activity on one of the protease processing sites in the viral Pol polyprotein precursor. Cleavage at this site was restored by a second-site substitution in the substrate replacing an aspartic acid with either glycine or asparagine. These results suggest that the glutamic acid...

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PMID: 7886951
DOI: 10.1006/viro.1995.1107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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