Article
Retroviral infection (HTLV-I) induces cytokine-regulated immunomodulation and cytotoxicity of medulloblastoma cells.
Journal of neuropathology and experimental neurology - 1 Mar 1995
Giraudon P, Bernard A, Malcus C, Dufay N, Desgranges C, Belin M F
Abstract excerpt
Primitive neuroectodermal tumors are thought to result from disturbed differentiation of neuroepithelial stem cells. These tumor cells retain the capacity to differentiate toward the neuron or glia phenotype under extrinsic stimuli. Previously, we have developed a model for the differentiation of a medulloblastoma cell line (Dev cells) induced by infection with the human retrovirus HTLV-I. This virus delivers...
Topics
- Cell Differentiation
- Child
- Cytokines
- Flow Cytometry
- Fluorescent Antibody Technique
- Genome, Viral
- HTLV-I Infections
- Histocompatibility Antigens Class I
- Human T-lymphotropic virus 1
- Humans