Understanding bone cell biology requires an integrated approach: reliable opportunities to study osteoclast biology in vivo.

Abstract excerpt

The relative simplicity of all in vitro methods to study bone cell biology will at best result in oversimplification of the development and functional capacity of the skeleton in vivo. We have shown this to be true for selected aspects of bone cell biology, but numerous other examples are available. One alternative is to undertake skeletal research in vivo. It is important that those in bone research be willing...

Topics

• Animals
• Bone Resorption
• Bone and Bones
• Humans
• In Vitro Techniques
• Models, Biological
• Mutation
• Osteoclasts
• Osteopetrosis
• Tooth Eruption