Article
A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK.
International journal of radiation biology - 1 Dec 1994
Taylor A M, McConville C M, Rotman G, Shiloh Y, Byrd P J
Abstract excerpt
In a study of ataxia-telangiectasia (A-T) in the UK, patients in 10 out of 60 families were shown to have a much lower level of chromosomal radiosensitivity compared with the majority of patients. In some patients the level of radiosensitivity was hardly distinguishable from normal. Patients in this group, however, could be distinguished clinically from the majority either by the later onset of severe cerebellar...
Topics
- Adolescent
- Adult
- Ataxia Telangiectasia
- Child
- Chromosomes, Human, Pair 11
- Female
- Genetic Variation
- Haplotypes
- Humans
- Male
- Radiation Tolerance
- United Kingdom