Article
A single cis-acting element in a short promoter segment of the gene encoding the interphotoreceptor retinoid-binding protein confers tissue-specific expression.
The Journal of biological chemistry - 20 Jan 1995
Bobola N, Hirsch E, Albini A, Altruda F, Noonan D, Ravazzolo R
Abstract excerpt
Interphotoreceptor retinoid-binding protein (IRBP) is the major protein component of the interphotoreceptor matrix. IRBP has a highly restricted tissue-specific expression in retinal photoreceptor cells and in a subgroup of pinealocytes. With the purpose of understanding how transcriptional regulation contributes to the expression of human IRBP, we have studied a short promoter fragment (from -123 to +18,...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- DNA-Binding Proteins
- Eye Proteins
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Nuclear Proteins