Article
Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin.
American journal of hematology - 1 Jan 1995
Okajima K, Abe H, Wagatsuma M, Okabe H, Takatsuki K
Abstract excerpt
Abnormal antithrombin III (AT III) was found in a 30-year-old woman who suffered from recurrent thrombosis during pregnancy and the postpartum period. Among her family members, only her father had recurrent episodes of deep vein thrombosis of the lower extremities, from his youth. The antithrombi...
Topics
- Adult
- Antithrombin III
- Arginine
- Base Sequence
- Chromatography, Affinity
- Factor X
- Female
- Heparin
- Histidine
- Humans
- Immunoelectrophoresis, Two-Dimensional
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Pregnancy
- Pregnancy Complications, Hematologic
- Puerperal Disorders