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Article

Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin.

American journal of hematology - 1 Jan 1995

Okajima K, Abe H, Wagatsuma M, Okabe H, Takatsuki K

Abstract excerpt

Abnormal antithrombin III (AT III) was found in a 30-year-old woman who suffered from recurrent thrombosis during pregnancy and the postpartum period. Among her family members, only her father had recurrent episodes of deep vein thrombosis of the lower extremities, from his youth. The antithrombin and antifactor Xa heparin cofactor activities of the proposita's plasma were 61% and 42% of normal, respectively. The...

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Identifiers

PMID: 7832187
DOI: 10.1002/ajh.2830480104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin.PMID 7832187Read ↗

Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity.Semantic proximity Read ↗

Familial variant of antithrombin III (AT III Bligny, 47Arg to His) associated with protein C deficiency.Semantic proximity Read ↗

Congenital antithrombin III deficiency (AT-III Kyoto): identification of a point mutation altering arginine-406 to methionine behind the reactive site.Semantic proximity Read ↗

Antithrombin III Sudbury: an Ala384----Pro mutation with abnormal thrombin-binding activity and thrombotic diathesis.Semantic proximity Read ↗

Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa.Semantic proximity Read ↗

Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family.Semantic proximity Read ↗

A novel missense mutation in the antithrombin III gene (Ala387-->Val) causing recurrent venous thrombosis.Semantic proximity Read ↗

Clinical and biochemical characterization of antithrombin III Franconville, a variant with Pro 41 Leu mutation.Semantic proximity Read ↗

Antithrombin III Kumamoto: identification of a point mutation and genotype analysis of the family.Semantic proximity Read ↗

Identification of a new SERPINC1 mutation in a Kazak family that alters the heparin binding capacity of antithrombin.Semantic proximity Read ↗

Antithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis.Semantic proximity Read ↗

Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).Semantic proximity Read ↗

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