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Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family.

Blood - 1 Mar 1992

Olds R J, Lane D A, Caso R, Panico M, Morris H R, Sas G, Dawes J, Thein S L

Abstract excerpt

Antithrombin III (AT) is a major plasma serine protease inhibitor and a member of the serpin family of proteins. We have characterized the molecular and genetic basis of AT Budapest, an inherited variant of AT that is associated with thrombotic disease in affected family members. A single amino acid substitution, 429Pro to Leu, was identified, occurring in a region of the molecule that is highly conserved in...

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PMID: 1536946

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