Article
Adhesion molecule deficiencies and their clinical significance.
Cell adhesion and communication - 1 Jul 1994
Etzioni A
Abstract excerpt
Adhesion molecules play a major role in the recruitment of neutrophils to the site of inflammation. Currently, two congenital hereditary Leukocyte Adhesion Deficiency (LAD) syndromes are recognized. LAD I is due to the absence of the beta subunit of the integrin molecule, while LAD II is caused by a deficiency of Sialy1 Lewis X, the neutrophil ligand for selectins. Clinically, both syndromes are characterized by...
Topics
- Animals
- Cell Adhesion Molecules
- Disease Models, Animal
- Humans
- Leukocyte-Adhesion Deficiency Syndrome
- Lewis X Antigen
- Phenotype
- Receptors, Leukocyte-Adhesion