3'-Demethoxy-3'-hydroxystaurosporine, a novel staurosporine analogue produced by a blocked mutant.

doi:10.7164/antibiotics.48.300

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Article

3'-Demethoxy-3'-hydroxystaurosporine, a novel staurosporine analogue produced by a blocked mutant.

The Journal of antibiotics - 1 Apr 1995

Hoehn P, Ghisalba O, Moerker T, Peter H H

Abstract excerpt

3'-Demethoxy-3'-hydroxystaurosporine, 1 (CGP 58,546), a novel staurosporine analogue, was isolated from a mutant of Streptomyces longisporoflavus R19 blocked in the last step of the biosynthetic pathway. CGP 58,546 was less potent than staurosporine, but it showed a more selective inhibition patt...

Topics

Alkaloids
Chemical Phenomena
Chemistry, Physical
Fermentation
Magnetic Resonance Spectroscopy
Molecular Structure
Mutagenesis
Mutation
Spectrometry, Mass, Fast Atom Bombardment
Staurosporine
Streptomyces

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