Article
The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma.
The Journal of biological chemistry - 2 Jun 1995
Ji L, Arcinas M, Boxer L M
Abstract excerpt
We have identified an in vivo footprint over the PuF site on the translocated c-myc allele in Burkitt's lymphoma cells. The PuF site on the silent normal c-myc allele was unoccupied. We demonstrated by electrophoretic mobility shift assay, electrophoretic mobility shift assay with antibody, UV cr...
Topics
- Alleles
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Burkitt Lymphoma
- Cell Line
- DNA Primers
- Genes, myc
- Humans
- Molecular Sequence Data
- Monomeric GTP-Binding Proteins
- NM23 Nucleoside Diphosphate Kinases
- Nucleoside-Diphosphate Kinase
- Transcription Factors
- Transcriptional Activation
- Translocation, Genetic
- Tumor Cells, Cultured