Role for the histone-like protein H-NS in growth phase-dependent and osmotic regulation of sigma S and many sigma S-dependent genes in Escherichia coli.

Abstract excerpt

The sigma S subunit of RNA polymerase (encoded by the rpoS gene) is the master regulator in a complex regulatory network that controls stationary-phase induction and osmotic regulation of many genes in Escherichia coli. Here we demonstrate that the histone-like protein H-NS is also a component of this network, in which it functions as a global inhibitor of gene expression during the exponential phase of growth....

Topics

• Bacterial Outer Membrane Proteins
• Bacterial Proteins
• Base Sequence
• Cell Division
• DNA-Binding Proteins
• Escherichia coli
• Gene Expression Regulation, Bacterial
• Molecular Sequence Data
• Mutation
• Osmolar Concentration