Article
A search for uniparental disomy in carriers of supernumerary marker chromosomes.
European journal of human genetics : EJHG - 1 Jan 1995
James R S, Temple I K, Dennis N R, Crolla J A
Abstract excerpt
As there is some evidence that individuals bearing supernumerary marker chromosomes (SMCs) might have an increased risk of being uniparentally disomic for the structurally normal homologues of the SMC, we made a systematic search for uniparental disomy of the autosomal homologues from which SMCs were derived. Of the 22 families studied, a biparental origin of the normal homologues was demonstrated in 21, and 1...
Topics
- Chromosome Aberrations
- Chromosomes, Human, Pair 6
- Female
- Genetic Markers
- Humans
- Karyotyping
- Male
- Phenotype
- Ring Chromosomes