FISH and molecular study of autosomal supernumerary marker chromosomes excluding those derived from chromosomes 15 and 22: I. Results of 26 new cases.

doi:10.1002/(sici)1096-8628(19980203)75:4<355::aid-ajmg4>3.0.co;2-p

Article

FISH and molecular study of autosomal supernumerary marker chromosomes excluding those derived from chromosomes 15 and 22: I. Results of 26 new cases.

American journal of medical genetics - 3 Feb 1998

Crolla J A, Long F, Rivera H, Dennis N R

Abstract excerpt

The chromosomal origins and in some cases the molecular composition of 26 autosomal supernumerary marker chromosomes (SMC) were identified using combined fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) techniques. Fifteen were de novo, 4 maternally and 2 paternally t...

Topics

Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 22
Female
Genetic Markers
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Pedigree
Phenotype
Polymerase Chain Reaction

FISH and molecular study of autosomal supernumerary marker chromosomes excluding those derived from chromosomes 15 and 22: I. Results of 26 new cases.

Abstract excerpt

Topics

Discuss the evidence