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Article

Comparative study of the genetic variability in thymidine kinase and glycoprotein B genes of herpes simplex viruses by the RNase A mismatch cleavage method.

Virus research - 1 Feb 1995

Rojas J M, Dopazo J, Santana M, López-Galíndez C, Tabarés E

Abstract excerpt

The variability of herpes simplex viruses has been measured using the RNAse A mismatch cleavage method in two genes: thymidine kinase and glycoprotein B of both HSV-1 and HSV-2. This technique permitted us to study the variability of the virus with a greater level of resolution than restriction endonuclease analysis. The phylogenetic trees obtained for the different genes allowed us to identify consistent...

Topics

Animals
Chlorocebus aethiops
DNA, Viral
Genetic Variation
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Nucleic Acid Hybridization
Phylogeny
RNA Probes
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonuclease, Pancreatic

Thymidine Kinase

Vero Cells

Viral Envelope Proteins

Source

Identifiers

PMID: 7762293
DOI: 10.1016/0168-1702(94)00097-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7762293-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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