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Article

Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995

Ripmaster T L, Shiba K, Schimmel P

Abstract excerpt

Because of variations in tRNA sequences in evolution, tRNA synthetases either do not acylate their cognate tRNAs from other organisms or execute misacylations which can be deleterious in vivo. We report here the cloning and primary sequence of a 958-aa Saccharomyces cerevisiae alanyl-tRNA synthetase. The enzyme is a close homologue of the human and Escherichia coli enzymes, particularly in the region of the...

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Identifiers

PMID: 7761427
DOI: 10.1073/pnas.92.11.4932
PMCID: PMC41821

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