Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen.

doi:10.1073/pnas.92.11.4932

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Article

Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995

Ripmaster T L, Shiba K, Schimmel P

Abstract excerpt

Because of variations in tRNA sequences in evolution, tRNA synthetases either do not acylate their cognate tRNAs from other organisms or execute misacylations which can be deleterious in vivo. We report here the cloning and primary sequence of a 958-aa Saccharomyces cerevisiae alanyl-tRNA synthet...

Topics

Alleles
Amino Acid Sequence
Amino Acyl-tRNA Synthetases
Animals
Arabidopsis
Base Sequence
Bombyx
Cell Division
DNA Primers
Escherichia coli
Genes, Bacterial
Hominidae
Humans
Leucine-tRNA Ligase
Molecular Sequence Data

Source

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Identifiers

PMID: 7761427
DOI: 10.1073/pnas.92.11.4932
PMCID: PMC41821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7761427-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Polymerase Chain Reaction

Saccharomyces cerevisiae

Sequence Homology, Amino Acid