Administration of 13-cis-retinoic acid to dairy cattle. 2. Phenotype of blood leukocytes and production of immunoglobulin.

Abstract excerpt

Eight Holstein dairy cattle were assigned randomly to treatments in three replicate experiments evaluating the effects of 13-cis-retinoic acid on mononuclear leukocyte function. Treatments were i.m. injections of 0 (vehicle only), 100, 200, or 400 mg/d of 13-cis-retinoic acid in dimethylsulfoxide for 7 consecutive d. Peripheral blood was collected before treatment and periodically for 18 d after initiation of...

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