Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration.

doi:10.1016/0092-8674(95)90333-x

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Article

Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration.

Cell - 21 Apr 1995

Guo L, Degenstein L, Dowling J, Yu Q C, Wollmann R, Perman B, Fuchs E

Abstract excerpt

BPAG1 is the major antigenic determinant of autoimmune sera of bullous pemphigoid (BP) patients. It is made by stratified squamous epithelia, where it localizes to the inner surface of specialized integrin-mediated adherens junctions (hemidesmosomes). To explore the function of BPAG1 and its relation to BP, we targeted the removal of the BPAG1 gene in mice. Hemidesmosomes are otherwise normal, but they lack the...

Topics

Animals
Autoantigens
Carrier Proteins
Cell Movement
Collagen
Cytoskeletal Proteins
Cytoskeleton
Desmosomes
Dystonia
Dystonin
Epithelium
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Nerve Degeneration

Nerve Tissue Proteins

Non-Fibrillar Collagens

Pemphigoid, Bullous

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7736575
DOI: 10.1016/0092-8674(95)90333-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7736575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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