Article
[Benzo(a)pyrene pretreatment of Drosophila simulans mutant strain results in the induction of aberrant isoform of cytochrome P-450 with increased capacity to metabolize benzo(a)pyrene].
Biulleten' eksperimental'noi biologii i meditsiny - 1 Aug 1991
Fuks Siu, Shpigel'man V S, Safaev R D, Khovanova E M, Belitskiĭ G A
Abstract excerpt
The basal level of benzo(a)pyrene monooxygenase, epoxide hydrolase and glutathione S-transferase activity as well as the content of cytochrome P-450 were found the same in both compared benzo(a)pyrene (BP) sensitive D. simulans strain 364yv and BP-resistant wild one (Turku). Phenobarbital pretrea...
Topics
- Animals
- Benzo(a)pyrene
- Cytochrome P-450 Enzyme System
- Drosophila
- Electrophoresis, Polyacrylamide Gel
- Epoxide Hydrolases
- Gene Expression Regulation
- Glutathione Transferase
- Mutation