Article
Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly.
Nature genetics - 1 Jan 1995
Andrikopoulos K, Liu X, Keene D R, Jaenisch R, Ramirez F
Abstract excerpt
The tissue-specific organization of collagen molecules into tridimensional macroaggregates determines the physiomechanical properties of most connective tissues, but the factors and mechanisms controlling this process are unknown. It has been postulated that quantitatively minor types V and XI collagen regulate the growth of type I and II collagen fibrils, respectively. To test this hypothesis, we created mice...
Topics
- Animals
- Base Sequence
- Collagen
- Connective Tissue Diseases
- DNA
- Disease Models, Animal
- Extracellular Matrix
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL