Targeting of neuronal subsets mediated by their sequentially expressed carbohydrate markers.

Abstract excerpt

The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation and arborization across the entire target region via mannose-specific recognition. Subsequently,...

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