Article
Phylogenetic conservation of the cell-type-specific Lan3-2 glycoepitope in Caenorhabditis elegans.
Development genes and evolution - 1 Sept 2010
Vansteenhouse Harper C, Horton Zachary A, O'Hagan Robert, Tai Mei-Hui, Zipser Birgit
Abstract excerpt
The biological function of a cell-type-specific glycosylation of an adhesion molecule belonging to the L1CAM immunoglobulin superfamily was previously determined in the nervous system of the embryonic leech, Hirudo medicinalis. The Lan3-2 glycoepitope is a surface marker of sensory afferent neurons and is required for their appropriate developmental collateral branching and synaptogenesis in the CNS. The chemical...
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