Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop.

doi:10.1128/JVI.67.8.4785-4796.1993

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop.

Journal of virology - 1 Aug 1993

Moore J P, Thali M, Jameson B A, Vignaux F, Lewis G K, Poon S W, Charles M, Fung M S, Sun B, Durda P J

Abstract excerpt

We have probed the structure of the C4 and V3 domains of human immunodeficiency virus type 1 gp120 by immunochemical techniques. Monoclonal antibodies (MAbs) recognizing an exposed gp120 sequence, (E/K)VGKAMYAPP, in C4 were differentially sensitive to denaturation of gp120, implying a conformational component to some of the epitopes. The MAbs recognizing conformation-sensitive C4 structures failed to bind to a...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Binding Sites, Antibody
Binding, Competitive
Cells, Cultured
Epitopes
Genetic Variation
HIV Envelope Protein gp120
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kinetics

Mice

Models, Structural

Molecular Sequence Data

Protein Conformation

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7687303
DOI: 10.1128/JVI.67.8.4785-4796.1993
PMCID: PMC237865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7687303-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop.PMID 7687303Read ↗

Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region.Semantic proximity Read ↗

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodiesSemantic proximity Read ↗

Immunological evidence for interactions between the first, second, and fifth conserved domains of the gp120 surface glycoprotein of human immunodeficiency virus type 1.Semantic proximity Read ↗

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.Semantic proximity Read ↗

Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoproteinSemantic proximity Read ↗

Variable-loop-deleted variants of the human immunodeficiency virus type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits.Semantic proximity Read ↗

Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.Semantic proximity Read ↗

A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein TrimerSemantic proximity Read ↗

Determination of essential amino acids involved in the CD4-independent tropism of the X4 human immunodeficiency virus type 1 m7NDK isolate: role of potential N glycosylations in the C2 and V3 regions of gp120.Semantic proximity Read ↗

Clade-specific differences between human immunodeficiency virus type 1 clades B and C: diversity and correlations in C3-V4 regions of gp120.Semantic proximity Read ↗

Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoproteinSemantic proximity Read ↗

Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.