Article
Molecular analysis of glycophorin C deficiency in human erythrocytes.
Blood - 15 May 1993
Winardi R, Reid M, Conboy J, Mohandas N
Abstract excerpt
Human erythrocyte glycophorin C plays a functionally important role in maintaining erythrocyte shape and regulating membrane mechanical stability. We report here the characterization of the glycophorins C and D deficiency in erythrocytes of the Leach phenotype. Glycophorin C gene is encoded by 4 exons. Amplification of reticulocyte cDNA from Leach phenotype and normal individuals generated a 140-bp fragment when...
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