Article
The cell attachment and spreading activity of vitronectin is dependent on the Arg-Gly-Asp sequence. Analysis by construction of RGD and domain deletion mutants.
Biochemical and biophysical research communications - 30 Apr 1993
Zhao Y, Sane D C
Abstract excerpt
The cell attachment activity of vitronectin has been ascribed to an Arg-Gly-Asp (RGD) sequence near the amino terminus. To verify the importance of the RGD sequence for cell binding, we created RAD and RGE vitronectin mutants and also deleted either the somatomedin B (delta S-rVN) or heparin (del...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Adhesion
- Cell Movement
- Cells, Cultured
- DNA
- Extracellular Matrix Proteins
- Glycoproteins
- Humans
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Sequence Deletion
- Vitronectin