Article
Mechanisms of rabies virus neutralization.
Virology - 1 May 1993
Flamand A, Raux H, Gaudin Y, Ruigrok R W
Abstract excerpt
The number of immunoglobulins necessary to neutralize rabies virus (CVS strain) was estimated using IgG and IgM monoclonal antibodies (MAb) specific to the three antigenic sites of the glycoprotein. It was estimated that below 130 IgG or 30 IgM bound per virions, infectivity was totally preserved. Neutralization occurred for an average of 1 or 2 IgG for 3 spikes and 1 IgM for 9 to 10 spikes on the virus surface....
Topics
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Cell Fusion
- Epitopes
- Glycoproteins
- Immunoglobulin G
- Immunoglobulin M
- Mutation
- Neutralization Tests
- Rabies virus
- Viral Envelope Proteins