Monoclonal antibodies which recognize the acidic configuration of the rabies glycoprotein at the surface of the virion can be neutralizing.

doi:10.1006/viro.1995.1356

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Monoclonal antibodies which recognize the acidic configuration of the rabies glycoprotein at the surface of the virion can be neutralizing.

Virology - 10 Jul 1995

Raux H, Coulon P, Lafay F, Flamand A

Abstract excerpt

Around 15% of our anti-glycoprotein monoclonal antibodies (MAbs) failed to neutralize the infectivity of the rabies virus during a 1-hr incubation at room temperature. In previous studies, we have demonstrated that it is possible to induce a massive conformational change of the glycoprotein population by incubating the virus at acidic pH. The conformational change is reversible and consequently viral infectivity...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Antibody Specificity
Antigens, Viral
DNA Mutational Analysis
Epitopes
Female
Glycoproteins
Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Neutralization Tests

Protein Conformation

Rabies virus

Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 7542418
DOI: 10.1006/viro.1995.1356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7542418-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Monoclonal antibodies which recognize the acidic configuration of the rabies glycoprotein at the surface of the virion can be neutralizing.PMID 7542418Read ↗

Identification of amino acids controlling the low-pH-induced conformational change of rabies virus glycoproteinSemantic proximity Read ↗

Studies on the escape mutants of rabies virus which are resistant to neutralization by a highly conserved conformational epitope-specific monoclonal antibody #1-46-12.Semantic proximity Read ↗

Mechanisms of rabies virus neutralization.Semantic proximity Read ↗

A Single Amino Acid Change in Rabies Virus Glycoprotein Increases Virus Spread and Enhances Virus PathogenicitySemantic proximity Read ↗

Antigenicity of rabies virus glycoprotein.Semantic proximity Read ↗

Mapping of epitopes and structural analysis of antigenic sites in the nucleoprotein of rabies virusSemantic proximity Read ↗

Immunodominant epitopes defined by a yeast-expressed library of random fragments of the rabies virus glycoprotein map outside major antigenic sites.Semantic proximity Read ↗

Folding of rabies virus glycoprotein: epitope acquisition and interaction with endoplasmic reticulum chaperonesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.