Article
Relationship between c-Kit expression and proliferation in acute myeloblastic leukemia cell lines.
Journal of cellular physiology - 1 Feb 1993
Tohda S, Yang G S, Ashman L K, McCulloch E A, Minden M D
Abstract excerpt
We have proposed that the transmembrane receptor encoded by the c-Kit protooncogene and its ligand play an important role in regulating the proliferation of blasts cells in acute myeloblastic leukemia (AML). To test this hypothesis, immunobeads were used to separate blasts from three Kit-expression positive cell lines into strongly Kit-protein positive and weakly Kit-protein positive fractions. The strongly...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Division
- Colony-Stimulating Factors
- Flow Cytometry
- Humans
- Leukemia, Myeloid, Acute
- Mice
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit