Directed mutation: paradigm postponed.

Abstract excerpt

Claims have been made in recent years that spontaneous mutational events are "directed" by (i) the presence in a selective medium of a single carbon source which the cells are unable to utilize (e.g. lactose), or (ii) the absence from a selective medium of an amino acid which the cells are unable to make for themselves (e.g. tryptophan). In resurrecting the previously rejected hypothesis of a "directed" origin...

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