Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo

Abstract excerpt

The term apoptosis was proposed to define a type of cell death morphologically, biochemically, and molecularly distinct from necrosis, which plays a fundamental regulatory function in the control of the overall size of cell populations, being complementary but opposite to cell proliferation [Kerr et al. (1972): Br J Cancer 26:239-257]. This view has led to the appreciation that apoptosis is an integral part of...

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