Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance.

doi:10.1093/genetics/140.3.933

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Article

Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance.

Genetics - 1 Jul 1995

Kanik-Ennulat C, Montalvo E, Neff N

Abstract excerpt

Orthovanadate is a small toxic molecule that competes with the biologically important oxyanion orthophosphate. Orthovanadate resistance arises spontaneously in Saccharomyces cerevisiae haploid cells by mutation in a number of genes. Mutations selected at 3 nM sodium orthovanadate have different degrees of vanadate resistance, hygromycin sensitivity, detergent sensitivity and sporulation defects. Recessive...

Topics

Amino Acid Sequence
Base Sequence
Cinnamates
DNA Primers
Detergents
Drug Resistance, Microbial
Fungal Proteins
Genetic Complementation Test
Genotype
Glycoside Hydrolases
Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Golgi Apparatus

Hygromycin B

Molecular Sequence Data

Mutagenesis

Polymerase Chain Reaction

Saccharomyces cerevisiae

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7672592
DOI: 10.1093/genetics/140.3.933
PMCID: PMC1206677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7672592-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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