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c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

Cancer cell - 12 Feb 2018

Sanclemente Manuel, Francoz Sarah, Esteban-Burgos Laura, Bousquet-Mur Emilie, Djurec Magdolna, Lopez-Casas Pedro P, Hidalgo Manuel, Guerra Carmen, Drosten Matthias, Musteanu Monica, Barbacid Mariano

Abstract excerpt

A quarter of all solid tumors harbor KRAS oncogenes. Yet, no selective drugs have been approved to treat these malignancies. Genetic interrogation of the MAPK pathway revealed that systemic ablation of MEK or ERK kinases in adult mice prevent tumor development but are unacceptably toxic. Here, we demonstrate that ablation of c-RAF expression in advanced tumors driven by KrasG12V/Trp53 mutations leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29395869
DOI: 10.1016/j.ccell.2017.12.014

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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