Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.

Article

Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.

American journal of human genetics - 1 Sept 1995

Pickles A, Bolton P, Macdonald H, Bailey A, Le Couteur A, Sim C H, Rutter M

Abstract excerpt

The use of the family history method to examine the pattern of recurrence risks for complex disorders such as autism is not straightforward. Problems such as uncertain phenotypic definition, unreliable measurement with increased error rates for more distant relatives, and selection due to reduced...

Topics

Autistic Disorder
Diseases in Twins
Down Syndrome
Humans
Models, Genetic
Phenotype
Reaction Time
Recurrence
Risk Factors
Selection, Genetic

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