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Article

Hb Lulu Island (alpha 2 beta 2 107[G9]Gly-->Asp)-beta zero- thalassemia (codon 15; TGG-->TAG), a form of thalassemia intermedia.

American journal of hematology - 1 Sept 1995

Gray G R, Manson H E, Gu L H, Leonova JYe, Huisman T H

Abstract excerpt

Hb Lulu Island [beta 107(G9)Gly-->Asp] was discovered in an East Indian female who carried a common beta zero-thalassemia allele, i.e., codon 15, TGG-->TAG (is a stop codon) in trans. Both abnormalities were detected through sequencing of the amplified beta-globin genes and were confirmed by hybridization with 32P-labeled probes. Hb Lulu Island is mildly unstable with a borderline decrease in oxygen affinity; its...

Topics

Adult
Base Sequence
Codon
Female
Globins
Hemoglobins, Abnormal
Heterozygote
Humans
Molecular Sequence Data
Mutation
beta-Thalassemia

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Identifiers

PMID: 7668221
DOI: 10.1002/ajh.2830500106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7668221-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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